Total Serenity

Total Serenity

Doctor formulated mood enhancement & stress relief

Total Serenity combines powerful herbs from natural sources into one daily dose to help improve cognitive wellness and promote feelings of calmness†


What it does

  • Reduces stress
  • Enhances cognitive wellness & mood†
  • Provides healthy adrenal support†

How it works

  • Research shows that certain natural herbs can have a powerful effect on mood, cognitive health, and adrenal functioning which is why they have been used for centuries
  • We weren’t built for the 21st century and our “always on” lifestyle can leave us feeling drained, stressed, and not like ourselves anymore
  • Studies show that natural herbs can help support mental-well being and cognitive wellness by decreasing racing thoughts and promoting feelings of calmness

How to take

  • Take 3 Total Serenity veggie capsules once a day with 8 fl oz of water

Our 100% Satisfaction Guarantee

More than


Satisfied Customers

KaraMD products are made in an FDA-registered facility and are backed by a risk-free 90-Day Money-Back Guarantee. If the product does not work as intended, simply contact our friendly support team for a full refund.


3rd Party Lab Tested


Formulated In The USA

Gluten Free


What's Inside


This herb has been used for thousands of years to treat a variety of health conditions. Recent research shows that Ashwagandha helps to reduce stress, increase natural energy levels, and improve focus.

Studies have shown that Panax Ginseng can be an effective natural remedy that helps with memory, improved well-being, and a sense of calmness.

This mushroom is high in anti-inflammatory and antioxidant value which is why research suggests that it can help protect against cognitive issues, like dementia, and also help with feelings of anxiety and depression.

This essential amino acid has been linked to improved mental health as well as reduced levels of stress in recent studies. L-Theanine is commonly found in Green Tea, but the best part is that it counteracts the caffeine leading to less of the stimulating or “jittery” effects.

Research shows that lemon balm can help with natural relaxation and stress relief. In a recent study, participants reported feeling more calm and less stressed when taking lemon balm.

LongJack belongs to the Ginseng family and studies have shown that it can help reduce stress hormones while also naturally improving energy levels



Customer Reviews
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Andrew I.

This stuff is Dreamy

This is the stuff dreams are made of. I won't sleep without it.

Christine K.
United States United States

Best ashwagandha product on the market!

After searching for an ashwagandha product, I picked Total Serenity because it had other ingredients like lemon balm, mushrooms, and ginseng. I think this definitely boosts the results.

Libby M.

Must try

I’ve felt less stressed and some of the racing thoughts that keep me up at night have decreased so I’ve been sleeping better too.

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Our products are formulated by a medical doctor and made in an FDA-registered facility using only the finest, most responsibly sourced ingredients. We also use 3rd party lab testing to ensure our products meet strict quality and composition standards.

Total Serenity is a proprietary blend of Ashwagandha, Panax Ginseng, Lion Mane’s Mushroom, L-Theanine, and other natural herbs that have been carefully paired together to help reduce stress, decrease racing thoughts, and improve overall mood and cognitive health.

Take 3 Total Serenity vegetable capsules per day with 8 fluid ounces of water.

All of our supplements are made pursuant to strict guidelines and 3rd party lab tested in order to maintain quality and composition standards.

Our products are formulated in the USA and manufactured in an FDA-registered facility using responsibly sourced non-GMO, gluten free, and vegan-friendly natural ingredients.

Our products are formulated in the USA and manufactured in an FDA-registered facility using responsibly sourced non-GMO, gluten free, and vegan-friendly natural ingredients.

Please refer to the specific ingredients on the supplement facts panel of the product you are looking to purchase for additional information.

KaraMD is dedicated to ensuring our customers are satisfied with their results.

If you are not satisfied with your product, we offer a risk-free 90-day guarantee that allows you to contact our friendly customer service team for assistance in processing a refund.

Because we are dedicated to ensuring that our customers receive their products in a timely fashion, all orders are processed within 1-2 business days at our local fulfillment center and depending on the final destination of the order, transit times range between 3-7 business days.

We offer on-site discounts of 10% if you purchase any 3 or more products as well as 20% if you purchase any 4 or more products.

We also offer free shipping when you purchase 2 or more products.

You can also subscribe to our email newsletter or follow our social media channels which offer regular promotions and discounts as well as exclusive health content from Dr. Kara.

Everyone is different, so we recommend that you consult your physician prior to starting this or any dietary supplement.

If you would like to track, change, or cancel your order you can call our friendly customer service team at (800)-991-4518 or email at

Our dedicated agents will be able to assist you to ensure we meet your needs based on where your order is at in the process.

Although we do not require returns in order to use the 90-day guarantee, they do help us in our quality control processes and training.

If you would like to return your order, please call our friendly customer service team at (800)-991-4518 or email at so that a dedicated agent can assist you.

The KaraMD Difference

Risk Free Purchase

backed by a 90 day guarantee

Exclusive Savings

when you buy any 3 or 4 products

Doctor Formulated

products backed by science

Reliable Customer Service

no subscription or return hassles

Formulated in the USA

and made in an FDA-registered facility

3rd Party Lab Tested

products made with natural ingredients

Receive 10% off all orders of 3 or more products & 20% off all orders of 4 or more products. A minimum of 2 products must be purchased to unlock free shipping. Coupon codes and on-site discounts of 10% and 20% cannot be applied together.


Jaysing Salve, et al. “Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study” Cureus (2019). 

Reay Jonathon, et al. “Panax Ginseng (G115) improves aspects of working memory performance and subjective ratings of calmness in healthy young adults” Human Psychopharmacology (2010). 

Chong Pit, et al. “Therapeutic Potential of Hericium Erinaceus for Depressive Disorder” International Journal of Molecular Sciences (2020). 

Hidese Shinsuke, et al. “Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults” Nutrients (2019). 

Kennedy David, et al. “Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (lemon balm)” Psychosomatic Medicine (2004). 

Talbot Shawn, et al. “Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects” Journal of International Society of Sports Medicine (2013).

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